Cisplatin modality of action
WebApr 12, 2024 · Objective. To assess the clinical efficacy and safety of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for ovarian cancer. Methods. From April 2024 to November 2024, 66 patients with ovarian cancer were admitted to our hospital and randomly allocated to undergo intravenous chemotherapy … WebCyclophosphamide (pronounced sigh-clo-fos-fah-mide) is a type of chemotherapy. It is a treatment for a number of different types of cancer. You can have cyclophosphamide on its own, or in combination with other chemotherapy drugs. How cyclophosphamide works Cyclophosphamide works by damaging the DNA of cancer cells.
Cisplatin modality of action
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WebA quadruple modality, including ionizing radiation, hyperthermia, cisplatin and PARP1-i, was not more effective than either triple modality. ... which are the main target of Olaparib. In contrast to this triple modality, chemotherapy, e.g., cisplatin, is a systemic treatment, and the combination with Olaparib can potentially cause severe side ... WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
WebSoreness, redness and peeling on palms and soles of feet The skin on your hands and feet may become sore, red, or may peel. You may also have tingling, numbness, pain and … Cisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, mesothelioma, brain tumors and neuroblastoma. It is given by injection into a vein. Common side effects include bone marrow suppression, hearing problems, incl…
WebCarboplatin is an organoplatinum antineoplastic alkylating agent used in the treatment of advanced ovarian carcinoma. 9 Early clinical studies of carboplatin were performed in 1982. 7 Carboplatin was developed as an analog of cisplatin with reduced nephrotoxicity and vomiting. 3,7. Carboplatin was granted FDA approval on 3 March 1989. 8. Type ... Web2 This action results in inhibition of DNA synthesis, and to a lesser degree, in ... receiving concomitant admi nistration of cisplatin, cyclophosphamide, methotrexate or doxorubicin, receiving positive fluid balance during prolonged surgical procedures and who smoke. These are all risk factors that can predispose the patient to bleomycin ...
WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the …
WebIt helps to keep your mouth and teeth clean, drink plenty of fluids and avoid acidic foods such as lemons. Chewing gum can help to keep the mouth moist. Tell your doctor or nurse if you have ulcers. High temperature (fever) If you get a high temperature, let your healthcare team know straight away. rajiv rai sonamWebCisplatin therapy is restricted due to its nephrotoxicity. Nephrotoxicity caused by cisplatin is thought to be associated with inflammatory reactions among other mechanisms. rajiv ranjan jduWebCisplatin is administered in 500mL sodium chloride 0.9% over 60 minutes following the pre and post hydration protocol below. Infusion Fluid & Additives Volume Infusion Time Sodium Chloride 0.9% 1000mL 60 minutes Mannitol 20% 200mL 10 minutes OR Mannitol 10% 400mL 15 minutes ... rajiv ranjanrajiv ranjan jdu spokesperson biographyWebCisplatin is a type of chemotherapy. It destroys quickly dividing cells, such as cancer cells. Find out more about how chemotherapy works How do you have cisplatin? You have … rajiv ranaWebMay 1, 2005 · Cisplatin is a chemotherapeutic drug used in conjunction with IR to treat various types of cancer, including cervical carcinoma as well as head and neck cancers . … rajiv ranjan mishraWebThymoquinone (TQ) is the major constituent of Nigella sativa seed and has shown biological activity in various human carcinomas. However, few studies have reported its effect on esophageal carcinoma (EC). To explore the chemosensitive effect and dream mhanje kay