WebDiacylglycerol kinase zeta is an enzyme that in humans is encoded by the DGKZ gene. The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at ... WebDec 1, 2013 · The protein encoded by the DGKA gene (2.7.1.107) belongs to the eukaryotic diacylglycerol kinase family. It attenuates the second messenger diacylglycerol, that activates C1-containing proteins like members of the classical and novel PKCs, PKD, RasGRP and chimaerin families.
Diacylglycerol kinase as a possible therapeutic target for neuronal ...
WebProtein kinase C (PKC) isozymes belong to a family of Ser/Thr kinases whose activity is governed by reversible release of an autoinhibitory pseudosubstrate. For conventional and novel isozymes, this is effected by binding the lipid second messenger, diacylglycerol, but for atypical PKC isozymes, this is effected by binding protein scaffolds. WebA protein kinase is a kinase which selectively modifies ... as well as numerous chemical signals, including cAMP/cGMP, diacylglycerol, and Ca 2+ /calmodulin. One very … how many calories in a subway footlong
Diacylglycerol - an overview ScienceDirect Topics
WebOverview. Diacylglycerol is a compound found in small amounts in plant oils. Oils rich in diacylglycerol can be made in the lab and used to replace fats in the diet. … Diacylglycerol kinase (DGK or DAGK) is a family of enzymes that catalyzes the conversion of diacylglycerol (DAG) to phosphatidic acid (PA), utilizing ATP as a source of the phosphate. In non-stimulated cells, DGK activity is low, allowing DAG to be used for glycerophospholipid biosynthesis, but on receptor … See more Currently, nine members of the DGK family have been cloned and identified. Although all family members have conserved catalytic domains and two cysteine rich domains, they are further classified into five … See more • Diacylglycerol+Kinase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • EC 2.7.1.107 See more WebC1 domain (also known as phorbol esters/diacylglycerol binding domain) binds an important secondary messenger diacylglycerol (DAG), as well as the analogous phorbol esters. [1] Phorbol esters can directly stimulate protein kinase C, PKC. Phorbol esters (such as PMA) are analogues of DAG and potent tumor promoters that cause a variety of ... high rise 123movies