Stat6 molecular weight

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August undefined, 2024

WebSTAT6 is mainly activated by cytokines interleukin-4 and interleukin-13. [5] Molecular biology [ edit] In the human genome, STAT6 protein is encoded by the STAT6 gene, … Web3. Robinson DR, Wu YM, Kalyana-Sundaram S, et al: Identification of recurrent NAB2-STAT6 fusions in solitary fibrous tumor by integrative sequencing. Nat Genet 2013;45(2):180-185. 4. Chmielecki J, Crago AM, Rosenberg M, et al: Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors. Nat Genet 2013;45(2):131-132

Anti-STAT6 antibody (ab88540) Abcam

WebHuman STAT6 has three isoforms; the molecular weights are 94, 82 and 74kD. The immunogen (phosphorylated peptide) is shared by these three isoforms. This antibody recognizes STAT6 Phospho (Tyr641) in all three isoforms. The predominant band detected is at 94 kD. Clone A15137E does not react with mouse. WebSTAT6 −/− mice have increased lethality, inflammation, and cytokine production in a noninfection induced model of endotoxemia, but reduced lethality and enhanced … skytec thermal gloves

Evidence for jak–stat interaction in channel catfish lymphoid cells

WebPhospho-Stat6 (Tyr641) Antibody detects endogenous levels of Stat6 only when phosphorylated at tyrosine 641. The antibody does not cross-react with the corresponding … WebWilliam E. Paul, in Encyclopedia of Hormones, 2003 IV IL-4 receptor signaling mechanisms. Addition of IL-4 to resting T cells leads to rapid phosphorylation of Stat6; each of the three … WebStat6 Antibody detects endogenous levels of total Stat6 protein. Species Reactivity: Human, Mouse, Rat Species predicted to react based on 100% sequence homology: The antigen sequence used to produce this antibody shares 100% sequence homology with the … skytel communications

STAT6 Antibody (6C10) (H00006778-M01): Novus …

Analysis of IL-4/STAT6 Signaling in Macrophages SpringerLink

WebApr 6, 2024 · To validate the potential mechanisms of QCWZD on UC and UCAC, dextran sodium sulfate (DSS, molecular weight: 36,000–50,000 Da, MP Biomedicals) and carcinogen azoxymethane (AOM, Sigma-Aldrich)-induced C57BL/6 mice were adopted to validate the protective effect of QCWZD on colitis and CAC. WebFeb 17, 2024 · AS1517499, a novel low molecular weight compound, is a derivative of 2-{[2-(4-hydroxyphenyl)ethyl]amino}pyrimidine-5-carboxamide and has been reported to be the most potent inhibitor of signal transducer and activator of transcription 6 (STAT6) . swedish american statelineWebOct 24, 2011 · STAT6 is expressed in normal kidneys (Fig. 1 A and B) yet the absence of PY-STAT6 indicates that it is normally kept in an inactive state. To test whether STAT6 can … sky telephone broadband and tv packages

"WebSTAT6 (predicted molecular weight 94kDa) has been found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL-4. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the ... " - Stat6 molecular weight

Stat6 molecular weight

Nuclear Localization and Cleavage of STAT6 Is Induced by Kaposi …

WebAnti-STAT6 antibody (ab88540) Datasheet Submit a review Submit a question References (1) Key features and details Mouse polyclonal to STAT6 Suitable for: WB, ICC/IF Reacts with: Human Isotype: IgG Get …

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WebStat6 is then released from the receptor, dimerizes, and is thought to contact the basal transcription machinery by binding to p300/CBP. While Stat6 is widely expressed in … WebDec 10, 2024 · Author summary STAT6 is a transcriptional factor that plays an important role in the extracellular cytokine and virus-mediated immune response. Extensive studies have revealed that the dysregulation of STAT6 is linked to the pathological features of virus-associated cancers. However, the molecular mechanism of STAT6 regulation by tumor …

WebSTAT6, also named as Signal transducer and activator of transcription 6, is a 847 amino acid protein, which belongs to the transcription factor STAT family. STAT6 forms a homodimer … WebMyBioSource.com's STAT6 (Ab-645) Antibody is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunohistochemistry, and Western Blot. ... Antigen STAT6; Molecular Weight 81,748 Da; Host Rabbit; Immunogen The antibody detects endogenous level of total STAT6 protein;

WebNumbers on the left refer to molecular weight standards. B, stabilization of dimeric STAT6. Proteins were expressed in HEG293 cells, and nuclear extracts prepared from IL-4-treated cells were subjected to DNA binding. WebMolecular analyses have discovered that almost all SFTs harbor an NAB2-STAT6 fusion gene, which is considered specific to this tumor type. Recent studies have suggested that STAT6 immunohistochemistry is a reliable surrogate for detection of the fusion gene. Our aim was to validate these findings by examining a large number of SFT cases and a ...

WebJan 13, 2013 · SFT-14 tumor expresses the larger 150-kDa NAB2-STAT6 fusion protein. SFT-10 and SFT-44 tumors both express the smaller, more common 90-kDa NAB2-STAT6 …

WebMay 1, 2024 · Part of the Methods in Molecular Biology book series (MIMB,volume 1966) Abstract Activation of signal transducer and activator of transcription 6 (STAT6) is a key signaling pathway in macrophage function, and is required for the so-called alternative (M2) activation of macrophages. swedish american urologyWebAug 26, 2024 · As a matter of fact, the final model simulation by Takahashi et al. (2024) suggested the following doses according to metabolizer status and weight to achieve target trough concentrations of 1.5–5.0 mg/L: for normal metabolizers: 16 mg/kg (15 kg weight), 12 mg/kg (15–30 kg weight), or 10 mg/kg (30 kg weight); doses were 33–50% lower for ... swedish american urgent care hoursWebApr 2, 2024 · Establecer su diagnóstico se ha vuelto más reproducible desde la identificación de la fusión de los genes NAB2-STAT6 por biología molecular, que lleva a la sobreexpresión de STAT6 por ... sky telephone contact numberWebMolecular Weight of Stat6: 119 kDa. Positive Controls: NIH/3T3 whole cell lysate: sc-2210, KNRK whole cell lysate: sc-2214 or BJAB whole cell lysate: sc-2207. DATA SELECT PRODUCT CITATIONS 1. Majka, M., et al. 2000. Stromal-derived factor 1 … sky telephone international callsWebSignal Transducer and Activator of Transcription 6 (STAT6) is a member of the Janus family tyrosine kinases (Jak)/ STAT signal transduction pathway and mediates cytokine … sky telephone number uk freeWebMA5-15659 detects STAT6 which has a predicted molecular weight of approximately 94kDa. Target Information STAT6 protein is a transcription factor activated by cytokines, … swedish american telephoneWebOct 14, 2011 · We now show that STAT6 is required for innate immune signaling in response to virus infection. Viruses or cytoplasmic nucleic acids trigger STING (also named MITA/ERIS) to recruit STAT6 to the endoplasmic reticulum, leading to STAT6 phosphorylation on Ser (407) by TBK1 and Tyr (641), independent of JAKs. … sky telephone number ireland